Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00541673" target="_blank" >RIV/67985823:_____/21:00541673 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/21:10430972

Result on the web

<a href="https://www.mdpi.com/2072-6643/13/2/437" target="_blank" >https://www.mdpi.com/2072-6643/13/2/437</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nu13020437" target="_blank" >10.3390/nu13020437</a>

Result language

angličtina

Original language name

Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity

Original language description

Preclinical evidence suggests that n-3 fatty acids EPA and DHA (Omega-3) supplemented as phospholipids (PLs) may be more effective than triacylglycerols (TAGs) in reducing hepatic steatosis. To further test the ability of Omega-3 PLs to alleviate liver steatosis, we used a model of exacerbated non-alcoholic fatty liver disease based on high-fat feeding at thermoneutral temperature. Male C57BL/6N mice were fed for 24 weeks a lard-based diet given either alone (LHF) or supplemented with Omega-3 (30 mg/g diet) as PLs (krill oil, w3PL) or TAGs (Epax 3000TG concentrate, w3TG), which had a similar total content of EPA and DHA and their ratio. Substantial levels of TAG accumulation (similar to 250 mg/g) but relatively low inflammation/fibrosis levels were achieved in the livers of control LHF mice. Liver steatosis was reduced by >40% in the omega 3PL but not omega 3TG group, and plasma ALT levels were markedly reduced (by 68%) in omega 3PL mice as well. Krill oil administration also improved hepatic insulin sensitivity, and its effects were associated with high plasma adiponectin levels (150% of LHF mice) along with superior bioavailability of EPA, increased content of alkaloids stachydrine and trigonelline, suppression of lipogenic gene expression, and decreased diacylglycerol levels in the liver. This study reveals that in addition to Omega-3 PLs, other constituents of krill oil, such as alkaloids, may contribute to its strong antisteatotic effects in the liver.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/GA17-11027S" target="_blank" >GA17-11027S: Dietary and pharmacological modulation of SCD1 as a tool for studying the link between ectopic lipid storage and insulin sensitivity in obesity</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nutrients

ISSN

2072-6643

e-ISSN

2072-6643

Volume of the periodical

13

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

24

Pages from-to

437

UT code for WoS article

000622893700001

EID of the result in the Scopus database

2-s2.0-85099993828