Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F22%3A00557065" target="_blank" >RIV/67985823:_____/22:00557065 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1371/journal.pgen.1009638" target="_blank" >https://doi.org/10.1371/journal.pgen.1009638</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pgen.1009638" target="_blank" >10.1371/journal.pgen.1009638</a>
Alternative languages
Result language
angličtina
Original language name
Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose
Original language description
Metabolic and neurological disorders are often comorbid, suggesting that biological pathways which orchestrate peripheral homeostasis and the integrity of the nervous system intersect. The genetic architecture behind these relationships is still poorly described, in part because molecular processes in the human brain are very difficult to study. We thus used a rodent genetic reference population to investigate links between adult hippocampal neurogenesis-a cellular plasticity mechanism important for learning flexibility-and metabolism. We measured adult neurogenesis in the family of 30 HXB/BXH rat recombinant inbred strains, who are characterised by stable differences in metabolism, behaviour, and gene expression levels.Because DNA variants affecting distinct traits segregated into different members of the family, it was possible to determine which of the previously published phenotypes correlated to adult neurogenesis due to shared genomic sequence. We found that expression levels of Tti2-a part of a specialised protein chaperone complex regulating stability of PIKK kinases-were concomitantly influencing adult neurogenesis and serum glucose levels. In human populations hundreds of genomic variants regulate TTI2 expression, potentially affecting brain function and glucose homeostasis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
<a href="/en/project/GA20-00939S" target="_blank" >GA20-00939S: Neuronal assemblies and circuits coding temporal associative memory traces as a basic biological model of episodic declarative memory</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS Genetics
ISSN
1553-7404
e-ISSN
1553-7404
Volume of the periodical
18
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
35
Pages from-to
e1009638
UT code for WoS article
000780213300003
EID of the result in the Scopus database
2-s2.0-85128526029