Cardiac immune cell infiltration associates with abnormal lipid metabolism
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F22%3A00561069" target="_blank" >RIV/67985823:_____/22:00561069 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.3389/fcvm.2022.948332" target="_blank" >https://doi.org/10.3389/fcvm.2022.948332</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcvm.2022.948332" target="_blank" >10.3389/fcvm.2022.948332</a>
Alternative languages
Result language
angličtina
Original language name
Cardiac immune cell infiltration associates with abnormal lipid metabolism
Original language description
CD36 mediates the uptake of long-chain fatty acids (FAs), a major energy substrate for the myocardium. Under excessive FA supply, CD36 can cause cardiac lipid accumulation and inflammation while its deletion reduces heart FA uptake and lipid content and increases glucose utilization. As a result, CD36 was proposed as a therapeutic target for obesity-associated heart disease. However, more recent reports have shown that CD36 deficiency suppresses myocardial flexibility in fuel preference between glucose and FAs, impairing tissue energy balance, while CD36 absence in tissue macrophages reduces efferocytosis and myocardial repair after injury. In line with the latter homeostatic functions, we had previously reported that CD36(-/-) mice have chronic subclinical inflammation. Lipids are important for the maintenance of tissue homeostasis and there is limited information on heart lipid metabolism in CD36 deficiency. Here, we document in the hearts of unchallenged CD36(-/-) mice abnormalities in the metabolism of triglycerides, plasmalogens, cardiolipins, acylcarnitines, and arachidonic acid, and the altered remodeling of these lipids in response to an overnight fast. The hearts were examined for evidence of inflammation by monitoring the presence of neutrophils and pro-inflammatory monocytes/macrophages using the respective positron emission tomography (PET) tracers, Cu-64-AMD3100 and Ga-68-DOTA-ECL1i. We detected significant immune cell infiltration in unchallenged CD36(-/-) hearts as compared with controls and immune infiltration was also observed in hearts of mice with cardiomyocyte-specific CD36 deficiency. Together, the data show that the CD36(-/-) heart is in a non-homeostatic state that could compromise its stress response. Non-invasive immune cell monitoring in humans with partial or total CD36 deficiency could help evaluate the risk of impaired heart remodeling and disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/LTAUSA18104" target="_blank" >LTAUSA18104: The role of antioxidant defense in the synthesis of antidiabetic lipokines</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cardiovascular Medicine
ISSN
2297-055X
e-ISSN
2297-055X
Volume of the periodical
9
Issue of the periodical within the volume
Aug 17
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
948332
UT code for WoS article
000848138000001
EID of the result in the Scopus database
2-s2.0-85137225070