Myocardial m6A regulators in postnatal development: effect of sex
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F22%3A00565798" target="_blank" >RIV/67985823:_____/22:00565798 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/22:00077760 RIV/00064203:_____/22:10452744 RIV/00216208:11130/22:10452744 RIV/00216208:11310/22:10452744
Result on the web
<a href="https://www.biomed.cas.cz/physiolres/pdf/2022/71_877.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2022/71_877.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934970" target="_blank" >10.33549/physiolres.934970</a>
Alternative languages
Result language
angličtina
Original language name
Myocardial m6A regulators in postnatal development: effect of sex
Original language description
N6-methyladenosine (m6A) is an abundant mRNA modification affecting mRNA stability and protein expression. It is a highly dynamic process, and its outcomes during postnatal heart development are poorly understood. Here we studied m6A machinery in the left ventricular (LV) myocardium of Fisher344 male and female rats (postnatal days one to ninety, P1-P90) using Western Blot. A downward pattern of target protein levels (demethylases FTO and ALKBH5, methyltransferase METTL3, reader YTHDF2) was revealed in male and female rat LVs during postnatal development. On P1, the FTO protein level was significantly higher in male LVs compared to female.
Czech name
—
Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/GJ19-04790Y" target="_blank" >GJ19-04790Y: Effect of perinatal hypoxia and low-protein diet on the role of RNA-demethylase FTO in the regulation of heart function and energy metabolism</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
1802-9973
Volume of the periodical
71
Issue of the periodical within the volume
6
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
877-882
UT code for WoS article
000908339300014
EID of the result in the Scopus database
2-s2.0-85144635907