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Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F23%3A00570226" target="_blank" >RIV/67985823:_____/23:00570226 - isvavai.cz</a>

  • Alternative codes found

    RIV/00023001:_____/23:00083716 RIV/00216208:11130/23:10448594 RIV/61989592:15110/23:73618651 RIV/00098892:_____/23:10157833 RIV/00064203:_____/23:10448594

  • Result on the web

    <a href="https://journals.lww.com/jhypertension/Fulltext/2023/01000/Endothelin_type_A_receptor_blockade_attenuates.11.aspx" target="_blank" >https://journals.lww.com/jhypertension/Fulltext/2023/01000/Endothelin_type_A_receptor_blockade_attenuates.11.aspx</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1097/HJH.0000000000003307" target="_blank" >10.1097/HJH.0000000000003307</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension

  • Original language description

    Objective:Evaluation of the effect of endothelin type A (ETA) receptor blockade on the course of volume-overload heart failure in rats with angiotensin II-dependent hypertension.Methods:Ren-2 renin transgenic rats (TGR) were used as a model of hypertension. Heart failure was induced by creating an aorto-caval fistula (ACF). Selective ETA receptor blockade was achieved by atrasentan. For comparison, other rat groups received trandolapril, an angiotensin-converting enzyme inhibitor (ACEi). Animals first underwent ACF creation and 2 weeks later the treatment with atrasentan or trandolapril, alone or combined, was applied, the follow-up period was 20 weeks.Results:Eighteen days after creating ACF, untreated TGR began to die, and none was alive by day 79. Both atrasentan and trandolapril treatment improved the survival rate, ultimately to 56% (18 of 31 animals) and 69% (22 of 32 animals), respectively. Combined ACEi and ETA receptor blockade improved the final survival rate to 52% (17 of 33 animals). The effects of the three treatment regimens on the survival rate did not significantly differ. All three treatment regimens suppressed the development of cardiac hypertrophy and lung congestion, decreased left ventricle (LV) end-diastolic volume and LV end-diastolic pressure, and improved LV systolic contractility in ACF TGR as compared with their untreated counterparts.Conclusion:The treatment with ETA receptor antagonist delays the onset of decompensation of volume-overload heart failure and improves the survival rate in hypertensive TGR with ACF-induced heart failure. However, the addition of ETA receptor blockade did not enhance the beneficial effects beyond those obtained with standard treatment with ACEi alone.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Hypertension

  • ISSN

    0263-6352

  • e-ISSN

    1473-5598

  • Volume of the periodical

    41

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    16

  • Pages from-to

    99-114

  • UT code for WoS article

    000921029000013

  • EID of the result in the Scopus database

    2-s2.0-85143180046