Current analytical methods to monitor type 2 diabetes medication in biological samples

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F23%3A00570364" target="_blank" >RIV/67985823:_____/23:00570364 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/23:43927221
Result on the web
<a href="https://doi.org/10.1016/j.trac.2022.116831" target="_blank" >https://doi.org/10.1016/j.trac.2022.116831</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.trac.2022.116831" target="_blank" >10.1016/j.trac.2022.116831</a>

Result language
angličtina
Original language name
Current analytical methods to monitor type 2 diabetes medication in biological samples
Original language description
We review the current analytical methods for analyzing type 2 diabetes (T2D) medication in human and animal samples. We discuss the advantages and limitations during sample preparation, separation, and detection of these drugs. Finally, we highlight the parameters to be considered for multi-targeted analytical methods and for assessing T2D medication adherence. By reviewing over 140 original papers, we can conclude that current analytical methods for T2D drug analysis involve: (1) extraction using protein precipitation with acetonitrile or methanol, (2) reversed-phase liquid chromatography separation using octadecyl (C18)-based columns with analysis time <20 min, and (3) electrospray ionization in positive ion mode with a triple quadrupole or quadrupole/linear ion trap mass analyzer. Methods for screening antidiabetics were limited to 1–5 analytes, far less than in other areas, such as analysis of cardiovascular agents, anticancer drugs, or drug screening for forensic services.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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