The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2R/R mice, a comparison with C57BL/6J and Adar2−/− mice strains

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00583680" target="_blank" >RIV/67985823:_____/24:00583680 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/24:10476692 RIV/00023752:_____/24:43921323

Result on the web

<a href="https://doi.org/10.1016/j.brainres.2023.148739" target="_blank" >https://doi.org/10.1016/j.brainres.2023.148739</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.brainres.2023.148739" target="_blank" >10.1016/j.brainres.2023.148739</a>

Result language

angličtina

Original language name

The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2R/R mice, a comparison with C57BL/6J and Adar2−/− mice strains

Original language description

Adar2-/- mice are a widely used model for studying the physiological consequences of reduced RNA editing. These mice are viable only when the Q/R editing site of the Gria2 subunit of the AMPA receptor is constitutively mutated to the codon for arginine, and Gria2R/R mice often serve as the sole control for Adar2-/- mice. Our study aimed to investigate whether ADAR2 inactivity and the Gria2R/R phenotype affect the rhythmicity of the circadian clock gene pattern and the expression of Gria1 and Gria2 subunits in the suprachiasmatic nucleus (SCN), hippocampus, parietal cortex and liver. Our data show that Gria2R/R mice completely lost circadian rhythmicity in the hippocampus compared to Adar2-/- mice. Compared to C57BL/6J mice, the expression profiles in the hippocampus and parietal cortex of Gria2R/R mice differ to the same extent as in Adar2-/-. No alterations were detected in the circadian profiles in the livers. These data suggest that the natural gradual postnatal increase in the editing of the Q/R site of the Gria2 subunit may be important for the development of circadian clockwork in some brain structures, and the use of Gria2R/R mice as the only control to Adar2-/- mice in the experiments dependent on the hippocampus and parietal cortex should therefore be considered.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain Research

ISSN

0006-8993

e-ISSN

1872-6240

Volume of the periodical

1826

Issue of the periodical within the volume

1 March

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

5

Pages from-to

148739

UT code for WoS article

001165646600001

EID of the result in the Scopus database

2-s2.0-85181063268