A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00585369" target="_blank" >RIV/67985823:_____/24:00585369 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.xgen.2024.100527" target="_blank" >https://doi.org/10.1016/j.xgen.2024.100527</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.xgen.2024.100527" target="_blank" >10.1016/j.xgen.2024.100527</a>
Alternative languages
Result language
angličtina
Original language name
A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats
Original language description
The seventh iteration of the reference genome assembly for Rattus norvegicus—mRatBN7.2—corrects numerous misplaced segments and reduces base-level errors by approximately 9-fold and increases contiguity by 290-fold compared with its predecessor. Gene annotations are now more complete, improving the mapping precision of genomic, transcriptomic, and proteomics datasets. We jointly analyzed 163 short-read whole-genome sequencing datasets representing 120 laboratory rat strains and substrains using mRatBN7.2. We defined ∼20.0 million sequence variations, of which 18,700 are predicted to potentially impact the function of 6,677 genes. We also generated a new rat genetic map from 1,893 heterogeneous stock rats and annotated transcription start sites and alternative polyadenylation sites. The mRatBN7.2 assembly, along with the extensive analysis of genomic variations among rat strains, enhances our understanding of the rat genome, providing researchers with an expanded resource for studies involving rats.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Genomics
ISSN
2666-979X
e-ISSN
2666-979X
Volume of the periodical
4
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
100527
UT code for WoS article
001230194400001
EID of the result in the Scopus database
2-s2.0-85189630510