Epitranscriptomic Regulations in the Heart
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00598033" target="_blank" >RIV/67985823:_____/24:00598033 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10497091
Result on the web
<a href="https://www.biomed.cas.cz/physiolres/pdf/2024/73_S185.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2024/73_S185.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.935265" target="_blank" >10.33549/physiolres.935265</a>
Alternative languages
Result language
angličtina
Original language name
Epitranscriptomic Regulations in the Heart
Original language description
RNA modifications affect key stages of the RNA life cycle, including splicing, export, decay, and translation. Epitranscriptomic regulations therefore significantly influence cellular physiology and pathophysiology. Here, we selected some of the most abundant modifications and reviewed their roles in the heart and in cardiovascular diseases: N6 -methyladenosine (m6 A), N6 ,2‘-O-dimethyladenosine (m6 Am), N1 -methyladenosine (m1 A), pseudouridine (Ψ), 5-methylcytidine (m5 C), and inosine (I). Dysregulation of epitranscriptomic machinery affecting these modifications vastly changes the cardiac phenotype and is linked with many cardiovascular diseases such as myocardial infarction, cardiomyopathies, or heart failure. Thus, a deeper understanding of these epitranscriptomic changes and their regulatory mechanisms can enhance our knowledge of the molecular underpinnings of prevalent cardiac diseases, potentially paving the way for novel therapeutic strategies.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
1802-9973
Volume of the periodical
73
Issue of the periodical within the volume
Suppl.1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
14
Pages from-to
"S185"-"S198"
UT code for WoS article
001295308400011
EID of the result in the Scopus database
2-s2.0-85202757602