Look for the Scaffold: Multifaceted Regulation of Enzyme Activity by 14-3-3 Proteins.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00598245" target="_blank" >RIV/67985823:_____/24:00598245 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10485787
Result on the web
<a href="https://www.biomed.cas.cz/physiolres/pdf/2024/73_S401.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2024/73_S401.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.935306" target="_blank" >10.33549/physiolres.935306</a>
Alternative languages
Result language
angličtina
Original language name
Look for the Scaffold: Multifaceted Regulation of Enzyme Activity by 14-3-3 Proteins.
Original language description
Enzyme activity is regulated by several mechanisms, including phosphorylation. Phosphorylation is a key signal transduction process in all eukaryotic cells and is thus crucial for virtually all cellular processes. In addition to its direct effect on protein structure, phosphorylation also affects protein-protein interactions, such as binding to scaffolding 14-3-3 proteins, which selectively recognize phosphorylated motifs. These interactions then modulate the catalytic activity, cellular localisation and interactions of phosphorylated enzymes through different mechanisms. The aim of this mini-review is to highlight several examples of 14-3-3 protein-dependent mechanisms of enzyme regulation previously studied in our laboratory over the past decade. More specifically, we address here the regulation of the human enzymes ubiquitin ligase Nedd4-2, procaspase-2, calciumcalmodulin dependent kinases CaMKK1/2, and death-associated protein kinase 2 (DAPK2) and yeast neutral trehalase Nth1.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10609 - Biochemical research methods
Result continuities
Project
<a href="/en/project/GA23-04686S" target="_blank" >GA23-04686S: The role of calcium and 14-3-3 protein in the regulation of human ubiquitin ligase Nedd4-2</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
1802-9973
Volume of the periodical
73
Issue of the periodical within the volume
Suppl.1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
12
Pages from-to
"S401"-"S412"
UT code for WoS article
001295308400022
EID of the result in the Scopus database
2-s2.0-85202716552