Postnatal surge of adipose-secreted leptin is a robust predictor of fat mass trajectory in mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00602677" target="_blank" >RIV/67985823:_____/24:00602677 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10491759
Result on the web
<a href="https://doi.org/10.1152/ajpendo.00237.2024" target="_blank" >https://doi.org/10.1152/ajpendo.00237.2024</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1152/ajpendo.00237.2024" target="_blank" >10.1152/ajpendo.00237.2024</a>
Alternative languages
Result language
angličtina
Original language name
Postnatal surge of adipose-secreted leptin is a robust predictor of fat mass trajectory in mice
Original language description
The transient postnatal increase in circulating leptin levels, known as leptin surge, may increase later susceptibility to diet-induced obesity in rodents. However, the source of leptin during the surge needs to be better characterized, and the long-term effects of leptin are contradictory. Characterization of the interaction of leptin with the genetic background, sex, and other factors is required. Here, we focused on the impact of circulating leptin levels and several related variables, measured in 2- and 4-wk-old i) obesity-prone C57BL/6 (B6) and ii) obesity-resistant A/J mice. In total, 264 mice of both sexes were used. Posttranscriptionally controlled leptin secretion from subcutaneous white adipose tissue, the largest adipose tissue depot in mice pups, was the primary determinant of plasma leptin levels. When the animals were randomly assigned standard chow or high-fat diet (HFD) between 12 and 24 wk of age, the obesogenic effect of HFD feeding was observed in B6 but not A/J mice. Only leptin levels at 2 wk, i.e., close to the maximum in the postnatal leptin surge, correlated with both body weight (BW) trajectory throughout the life and adiposity of the 24-wk-old mice. Leptin surge explained 13 and 7% of the variance in BW and adiposity of B6 mice, and 9 and 35% of the variance in these parameters in A/J mice, with a minor role of sex. Our results prove the positive correlation between the leptin surge and adiposity in adulthood, reflecting the fundamental biological role of leptin. This role could be compromised in subjects with obesity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
<a href="/en/project/NU20-07-00026" target="_blank" >NU20-07-00026: Changes of transcriptome during early postnatal development in humans: impact of premature birth on control of energy metabolism</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Physiology - Endocrinology And Metabolism
ISSN
0193-1849
e-ISSN
1522-1555
Volume of the periodical
327
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
"E719"-"E745"
UT code for WoS article
001379041400004
EID of the result in the Scopus database
2-s2.0-85210756205