A numerical algorithm for modeling cellular rearrangements in tissue morphogenesis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985840%3A_____%2F22%3A00556315" target="_blank" >RIV/67985840:_____/22:00556315 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/s42003-022-03174-6" target="_blank" >https://doi.org/10.1038/s42003-022-03174-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s42003-022-03174-6" target="_blank" >10.1038/s42003-022-03174-6</a>

Result language
angličtina
Original language name
A numerical algorithm for modeling cellular rearrangements in tissue morphogenesis
Original language description
Among morphological phenomena, cellular patterns in developing sensory epithelia have gained attention in recent years. Although physical models for cellular rearrangements are well-established thanks to a large bulk of experimental work, their computational implementation lacks solid mathematical background and involves experimentally unreachable parameters. Here we introduce a level set-based computational framework as a tool to rigorously investigate evolving cellular patterns, and study its mathematical and computational properties. We illustrate that a compelling feature of the method is its ability to correctly handle complex topology changes, including frequent cell intercalations. Combining this accurate numerical scheme with an established mathematical model, we show that the proposed framework features minimum possible number of parameters and is capable of reproducing a wide range of tissue morphological phenomena, such as cell sorting, engulfment or internalization. In particular, thanks to precise mathematical treatment of cellular intercalations, this method succeeds in simulating experimentally observed development of cellular mosaic patterns in sensory epithelia.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10101 - Pure mathematics

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)