Study of TiO2 Nanoparticle Generation for Follow-up Inhalation Experiments with Laboratory Animals.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F16%3A00463828" target="_blank" >RIV/67985858:_____/16:00463828 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/02786826.2016.1224803" target="_blank" >http://dx.doi.org/10.1080/02786826.2016.1224803</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/02786826.2016.1224803" target="_blank" >10.1080/02786826.2016.1224803</a>

Result language
angličtina
Original language name
Study of TiO2 Nanoparticle Generation for Follow-up Inhalation Experiments with Laboratory Animals.
Original language description
A method of long-lasting TiO2 nanoparticle generation was tested for use in follow-up studies of the health impacts of nanoparticles on laboratory animals during several weeks’ long exposure experiments. Nanoparticles were synthesized in an externally heated tube reactor by pyrolysis and oxidation of titanium tetraisopropoxide. Particle production was studied under varying reactor temperature, reactor flow rate, and precursor vapor pressure. A total of 264 h of particle generation were performed in four experimental campaigns using one batch of precursor without an observable decrease of particle production. As a result, particle production with number concentrations high above 1.0 £ 107 #/cm3 and with primary particle sizes well below 50 nm could be achieved in most of the investigated experimental conditions. Maximum of particle mass concentration reached the value 9500 mg/m3, which corresponds with emission rate 29 mg/min. The dependence of nanoparticle production and characteristics on experimental conditions was evaluated and the most suitable parameters for exposure experiments were specified. A comparison of the results with data from the literature shows that the material of the reactor plays a significant role in the process of particle formation.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
<a href="/en/project/GBP503%2F12%2FG147" target="_blank" >GBP503/12/G147: Centre for studies on toxicity of nanoparticles</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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