Dry Powder Inhaler of Colistimethate Sodium for Lung Infections in Cystic Fibrosis: Optimization of Powder Construction.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F19%3A00507425" target="_blank" >RIV/67985858:_____/19:00507425 - isvavai.cz</a>

Result on the web

<a href="http://hdl.handle.net/11104/0299807" target="_blank" >http://hdl.handle.net/11104/0299807</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/03639045.2019.1652636" target="_blank" >10.1080/03639045.2019.1652636</a>

Result language

angličtina

Original language name

Dry Powder Inhaler of Colistimethate Sodium for Lung Infections in Cystic Fibrosis: Optimization of Powder Construction.

Original language description

Colistimethate sodium (CMS) for treatment of lung infections in cystic fibrosis patient was transformed into a dry powder for inhalation by spray drying. Design of Experiment was applied for understanding the role of the spray drying process parameters on the critical quality attributes of the CMS spray-dried powders (SD) and agglomerates thereof. Eleven experimental SD microparticle powders were constructed under different process conditions according to a Central Composite Design. The SD microparticles were then agglomerated in soft pellets. Eleven physico-chemical characteristics of SD CMS microparticle powders or agglomerates thereof were selected as critical quality attributes.nThe yield of SD process was higher than 75%. The emitted fraction of agglomerates from RS01 inhaler was 75-84%, and the fine particle fraction (particles <5 µm) between 58-62%. The quality attributes of CMS SD powders and respective agglomerates that were significantly influenced by spray drying process parameters were residual solvent and drug content of the SD microparticles as well as bulk density and respirable dose of the agglomerates. These attributes were also affected by the combination of the process variables. The air aspiration rate was found as the most positively influential on drug and solvent content and respirable dose. The residual solvent content significantly influenced the powder bulk properties and aerodynamic behavior of the agglomerates, i.e. quality attributes that govern drug metering in the device and the particles lungs deposition. Agglomerates of colistimethate sodium SD microparticles, in combination with RS01 DPI, showed satisfactory results in terms of dose emitted and fine particle fraction.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/LTC17010" target="_blank" >LTC17010: Study on delivery efficiency of drugs dosed by aerosol inhalers to the target location in the respiratory tract</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Drug Development and Industrial Pharmacy

ISSN

0363-9045

e-ISSN

—

Volume of the periodical

45

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

1664-1673

UT code for WoS article

000484270800001

EID of the result in the Scopus database

2-s2.0-85071386908