Evaluation of multifunctional magnesium aluminosilicate materials as novel family of glidants in solid dosage products
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F21%3A00559344" target="_blank" >RIV/67985858:_____/21:00559344 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/21:43920575
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0378517320310395?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0378517320310395?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2020.120054" target="_blank" >10.1016/j.ijpharm.2020.120054</a>
Alternative languages
Result language
angličtina
Original language name
Evaluation of multifunctional magnesium aluminosilicate materials as novel family of glidants in solid dosage products
Original language description
The work was aimed at evaluating the efficiency of multifunctional magnesium aluminosilicate materials (MAS) as a novel glidant in solid dosage forms. MAS are known for their very low cohesive interactions and their utilization could avoid the disadvantages associated with conventional glidant usage. Flow properties of several mixtures comprising a model excipient (microcrystalline cellulose) and a glidant were characterized using a powder rheometer FT4. The mixtures were formulated to represent effects of glidant types, various levels of glidant loading, particle size and mixing time on flow properties of the model excipient. Pre-conditioning, shear testing, compressibility, flow energy measurements and an additional tapping test were carried out to monitor flow properties. Mixtures were analyzed employing scanning electron microscopy, using a detector of back-scattered electrons to identify a mechanism of MAS towards improving the mixture flow properties. All studied parameters were found to have substantial effects on mixture flow properties, but the effect of mixing time was much less important compared to mixtures based on traditional glidant. The mechanism of MAS glidant action was found to be different compared to that of traditional one, having less process sensitivity, so that MAS utilization as glidant could be advantageous for the formulation performance.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20402 - Chemical process engineering
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Pharmaceutics
ISSN
0378-5173
e-ISSN
1873-3476
Volume of the periodical
592
Issue of the periodical within the volume
JAN 5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
120054
UT code for WoS article
000600740100036
EID of the result in the Scopus database
2-s2.0-85096201390