Chiral helical scaffolds: Unlocking their potential in biomolecular interactions and biomedical applications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F25%3A00605045" target="_blank" >RIV/67985858:_____/25:00605045 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/25:73635952

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0734975024002076?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0734975024002076?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biotechadv.2024.108513" target="_blank" >10.1016/j.biotechadv.2024.108513</a>

Result language

angličtina

Original language name

Chiral helical scaffolds: Unlocking their potential in biomolecular interactions and biomedical applications

Original language description

In nature, various molecules possess spiral geometry. Such helical structures are even prevalent within the human body, represented classically by DNA and three-dimensional (secondary structure) protein folding. In this review, we chose helicenes and helicene-like structures –synthetically accessible carbon-rich molecules– as a compelling example of helically chiral scaffolds. Helicene chemistry, traditionally anchored in materials science, has been a subject of increasing interest in the biomedical field due to the unique optical and chiral properties of these helical structures. This review explores the diverse applications of helicenes in biomedicine, focusing on their role in cell imaging, protective coatings for implants, drug delivery systems, biosensors, and drug discovery. We discuss the unique properties of helicenes and helicene-like structures, highlighting their ability to form complex interactions with various biomolecules and their potential in the development of candidates for therapeutic agents. Recent advances in helicene derivatives with enhanced circularly polarized luminescence and other photochemical properties are also reviewed, underlining their utility in precise bio-imaging and diagnostic techniques. The review consolidates the current literature and emphasizes the growing importance of helicenes in bridging chemistry, materials science, and biology for innovative technological and biomedical applications.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10401 - Organic chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biotechnology Advances

ISSN

0734-9750

e-ISSN

1873-1899

Volume of the periodical

79

Issue of the periodical within the volume

1 March

Country of publishing house

GB - UNITED KINGDOM

Number of pages

22

Pages from-to

108513

UT code for WoS article

001399636200001

EID of the result in the Scopus database

2-s2.0-85214705261