Influence of polyacrylic acid nanoparticles on the elastic properties of RBCs membranes in patients with diabetes mellitus type 2
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985874%3A_____%2F15%3A00453579" target="_blank" >RIV/67985874:_____/15:00453579 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Influence of polyacrylic acid nanoparticles on the elastic properties of RBCs membranes in patients with diabetes mellitus type 2
Original language description
The influence of polyacrylic acid (PAA) derived nanoparticles, a star shaped macromolecules with/nhydrodynamic radius of 14 nm, on the structure and mechanical properties of red blood cells (RBCs) membranes in/npatients with diabetes mellitus type 2 by AFM method has been studied. Their behavior has been compared to that/nof linear PAAs with different degrees of polymerization. Significant changes in the structure of RBCs membranes/ndid not occur and traces of polymer chains or nanoparticles were not found. It was shown, that changes of the/nelasticity modulus were observed after cells incubated in the presence of linear PAA with Mn =20000 Da and/n225000 Da, due to the interaction of polymer chains with the components of the cell membrane. The star shaped/nNPs with Mn = 57000 Da lead to the smallest changes in the structure and properties cells membrane. Thus, these/nNPs can be recommended for drug delivery applications.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BK - Liquid mechanics
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Series on biomechanics
ISSN
1313-2458
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
4
Country of publishing house
BG - BULGARIA
Number of pages
8
Pages from-to
12-19
UT code for WoS article
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EID of the result in the Scopus database
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