Enhanced levels of mitochondrial enzyme 17?-hydroxysteroid dehydrogenase type 10 in patients with Azheimer disease and multiple sclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F09%3A00341047" target="_blank" >RIV/67985882:_____/09:00341047 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Enhanced levels of mitochondrial enzyme 17?-hydroxysteroid dehydrogenase type 10 in patients with Azheimer disease and multiple sclerosis

Original language description

This paper describes detection of mitochondrial 17-HSD10 enzyme using a surface plasmon resonance (SPR) biosensor and ELISA method. 17-HSD10 enzyme is involved in pathogenesis of Alzheimer disease (AD) and represents a potential target for AD diagnostics. It was demonstrated that the reported SPR biosensor is capable of detecting 17?-HSD10/A?s complex in CSF samples and it was revealed the patients with AD exhibited elavated levels of 17?-HSD10/A?s complex compared to the controls.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

JB - Sensors, detecting elements, measurement and regulation

OECD FORD branch

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Project

<a href="/en/project/NR9322" target="_blank" >NR9322: Amyloid ß peptides and mitochondrial enzyme 17ß-hydroxysteroid dehydrogenase type 10, possibility of Alzheimer disease diagnostics using optical biosensors</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular BioSystems

ISSN

1742-206X

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

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UT code for WoS article

000269835400010

EID of the result in the Scopus database

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