Rational design of sensor for broadband dielectric spectroscopy of biomolecules

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F18%3A00490476" target="_blank" >RIV/67985882:_____/18:00490476 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.snb.2018.05.124" target="_blank" >http://dx.doi.org/10.1016/j.snb.2018.05.124</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.snb.2018.05.124" target="_blank" >10.1016/j.snb.2018.05.124</a>

Result language

angličtina

Original language name

Rational design of sensor for broadband dielectric spectroscopy of biomolecules

Original language description

Knowledge of electromagnetic properties of biomolecules is essential for a fundamental understanding of electric field interaction with biosystems and for development of novel biomedical diagnostic and therapeutic methods. To enable systematic analysis of the dielectric properties of biomolecule solutions we presented here a method for a rational design of radiofrequency and microwave chip for quantitative dielectric sensing. At first, we estimated the primary frequency band of interest using a relaxation time of targeted molecule via the Stokes–Einstein–Debye equation. Then we proposed a microwave sensing chip for the estimated frequency band and evaluated its performance using both analytical modeling and numerical electromagnetic simulations. We fabricated the chip and experimentally demonstrated that we can extract the complex permittivity (0.5–40 GHz) of the water solution of alanine – one of the most common proteinogenic amino acids – without any calibration liquid and with about 20-fold smaller volume than with commercial methods. The observed dependence of extracted complex permittivity on the alanine concentration was interpreted using molecular dynamics simulations. The procedure we described here can be applied for the development of dielectric sensing method of any polar biomolecule solution

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20201 - Electrical and electronic engineering

Project

<a href="/en/project/GA15-17102S" target="_blank" >GA15-17102S: Radio-frequency characterization of microtubules using micro- and nanosensors</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Sensors and Actuators B - Chemical

ISSN

0925-4005

e-ISSN

—

Volume of the periodical

273

Issue of the periodical within the volume

10 November

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

62-69

UT code for WoS article

000441519000009

EID of the result in the Scopus database

2-s2.0-85048328061