Surface-plasmon optical-heterodyne clock biosensor
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F18%3A00499896" target="_blank" >RIV/67985882:_____/18:00499896 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.snb.2018.06.028" target="_blank" >http://dx.doi.org/10.1016/j.snb.2018.06.028</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.snb.2018.06.028" target="_blank" >10.1016/j.snb.2018.06.028</a>
Alternative languages
Result language
angličtina
Original language name
Surface-plasmon optical-heterodyne clock biosensor
Original language description
Surface-plasmon resonance (SPR) sensors represent a formidable technology for molecular biology and bioanalytics applications. Here, we devise a new interrogation architecture that transforms a standard SPR chip into an optical-heterodyne clock detector comparable with the best SPR instruments. The key ingredients are (i) the conversion of refractive-index changes on the SPR chip into frequency shifts of an oscillatory electronic signal (ii) a differential probe & reference optical-cavity scheme that cancels out most source/detector noise contributions. A rigorous characterization of the sensor performance with the integration time demonstrates a refractive-index resolution on the 10(-8)-RIU level over a 1-s timescale using a bare, unstabilized SPR element. A bio-sensing test with a functionalized surface interfaced with a microfluidic flow-cell is carried out, showing detection of streptavidin via covalent bond down to concentrations of 90 fg/mm(2)
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10306 - Optics (including laser optics and quantum optics)
Result continuities
Project
<a href="/en/project/GBP205%2F12%2FG118" target="_blank" >GBP205/12/G118: Nanobiophotonics for future health care</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sensors and Actuators B - Chemical
ISSN
0925-4005
e-ISSN
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Volume of the periodical
273
Issue of the periodical within the volume
10 November
Country of publishing house
CH - SWITZERLAND
Number of pages
6
Pages from-to
336-341
UT code for WoS article
000441519000043
EID of the result in the Scopus database
2-s2.0-85048716871