Plasmonic biosensor based on a gold nanostripe array for detection of microRNA related tonmyelodysplastic syndromes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F21%3A00553141" target="_blank" >RIV/67985882:_____/21:00553141 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.snb.2021.130629" target="_blank" >https://doi.org/10.1016/j.snb.2021.130629</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.snb.2021.130629" target="_blank" >10.1016/j.snb.2021.130629</a>

Result language

angličtina

Original language name

Plasmonic biosensor based on a gold nanostripe array for detection of microRNA related tonmyelodysplastic syndromes

Original language description

We present a new optical biosensor based on surface plasmons excited on an array of gold nanostripes via attenuated total reflection. We investigate performance of the biosensor using a theoretical model that considers both optical and mass transport aspects. The analysis of optical aspects employs two different approaches: a complex model incorporating optical characteristics of the nanostructure as well as the noise characteristics of the optical readout system and a simple model based solely on the figure of merit of the nanostructure. The theoretical analysis suggests that the optimized biosensor is able to detect molecular analytes at concentrations lower by a factor of - 10 than conventional surface plasmon resonance biosensors. In order to validate the theoretical model, we characterize the gold nanostripe arrays of different designs in model refractometric and biosensing experiments. We show that the nanoplasmonic sensor exhibits refractive index sensitivity of 1989 nm/RIU and refractive index resolution down to 3.6 x 10-7RIU. In addition, we use the nanoplasmonic biosensor for the detection of a microRNA biomarker of myelodysplastic syndromes (miRNA-125b) and demonstrate that the biosensor can detect miRNA-125b at concentrations down to - 17 pM

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10306 - Optics (including laser optics and quantum optics)

Project

<a href="/en/project/GX20-23787X" target="_blank" >GX20-23787X: Novel biophotonic tools for investigation of cellular processes</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Sensors and Actuators B - Chemical

ISSN

0925-4005

e-ISSN

0925-4005

Volume of the periodical

347

Issue of the periodical within the volume

15 November

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

130629

UT code for WoS article

000697414400005

EID of the result in the Scopus database

2-s2.0-85113691144