The Sustainable Release of Vancomycin and Its Degradation Products From Nanostructured Collagen/Hydroxyapatite Composite Layers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985891%3A_____%2F16%3A00465814" target="_blank" >RIV/67985891:_____/16:00465814 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10327688 RIV/00216208:11130/16:10327688 RIV/00064203:_____/16:10327688 RIV/68407700:21220/16:00237451
Result on the web
<a href="http://dx.doi.org/10.1016/S0022-3549(15)00175-6" target="_blank" >http://dx.doi.org/10.1016/S0022-3549(15)00175-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/S0022-3549(15)00175-6" target="_blank" >10.1016/S0022-3549(15)00175-6</a>
Alternative languages
Result language
angličtina
Original language name
The Sustainable Release of Vancomycin and Its Degradation Products From Nanostructured Collagen/Hydroxyapatite Composite Layers
Original language description
Infections of the musculoskeletal system present a serious problem with regard to the field of orthopedic and trauma medicine. The aim of the experiment described in this study was to develop a resorbable nanostructured composite layer with the controlled elution of antibiotics. The layer is composed of collagen, hydroxyapatite nanoparticles, and vancomycin hydrochloride (10 wt%). The stability of the collagen was enhanced by means of cross-linking. Four cross-linking agents were studied, namely an ethanol solution, a phosphate buffer solution of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide, genipin, and nordihydroguaiaretic acid. High performance liquid chromatography was used so as to characterize the in vitro release rates of the vancomycin and its crystalline degradation antibiotically inactive products over a 21-day period. The maximum concentration of the released active form of vancomycin (approximately 265 mg/L) exceeded the minimum inhibitory concentration up to an order of 17 times without triggering the burst releasing effect. At the end of the experiment, the minimum inhibitory concentration was exceeded by up to 6 times (approximately 100 mg/L). It was determined that the modification of collagen with hydroxyapatite nanoparticles does not negatively influence the sustainable release of vancomycin. The balance of vancomycin and its degradation products was observed after 14 days of incubation. (C) 2016 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
JI - Composite materials
OECD FORD branch
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Result continuities
Project
<a href="/en/project/TA04010330" target="_blank" >TA04010330: Development of resorbable collagen-calcium phosphate nanolayer with controlled elution of antibiotics for implants survival rate enhancement</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pharmaceutical Sciences
ISSN
0022-3549
e-ISSN
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Volume of the periodical
105
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1288-1294
UT code for WoS article
000381769100032
EID of the result in the Scopus database
2-s2.0-84964489842