A nanocomposite layer on the basis of collagen nanofibers, and a method of preparation thereof
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985891%3A_____%2F20%3A00533071" target="_blank" >RIV/67985891:_____/20:00533071 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21220/20:00341885
Result on the web
<a href="https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20200805&DB=&locale=en_EP&CC=EP&NR=3311854B1&KC=B1&ND=1#" target="_blank" >https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20200805&DB=&locale=en_EP&CC=EP&NR=3311854B1&KC=B1&ND=1#</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
A nanocomposite layer on the basis of collagen nanofibers, and a method of preparation thereof
Original language description
The subject of the invention is a bioactive nanocomposite layer prepared by the combination of electrospinning and electroblowing of a collagen solution comprising hydroxyapatite nanoparticles and poly(ethylene oxide), where, after the preparation and the crosslinking, the layer consists of 75 to 100 wt. % of collagen type I fibres, 5 - 15 wt. % of hydroxyapatite, and 0 - 1 wt. % of poly(ethylene oxide). The subject of this invention is also a method of production of said layer and a method of depositing antibiotics for a more effective releasing thereof without increasing the cytotoxicity. Said method comprises the impregnation of crosslinked sterilized collagen/hydroxyapatite layers with antibiotics in the form of a solution. The subject of the invention also comprises orthopaedic and dental implants based on metal or metal alloys, electrostatically coated with said composite layer based on collagen nanofibers with integrated hydroxyapatite nanoparticles and an antibiotic or a combination of antibiotics.
Czech name
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Czech description
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Classification
Type
P - Patent
CEP classification
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OECD FORD branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
Result continuities
Project
<a href="/en/project/TA04010330" target="_blank" >TA04010330: Development of resorbable collagen-calcium phosphate nanolayer with controlled elution of antibiotics for implants survival rate enhancement</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Patent/design ID
EP3311854
Publisher
EPO_1 -
Publisher name
European Patent Office
Place of publication
Munich, The Hague, Berlin, Vienna, Brussels
Publication country
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Date of acceptance
Aug 5, 2020
Owner name
Ústav struktury a mechaniky hornin AV ČR, v. v. i. - České vysoké učení technické v Praze, Fakulta strojní - ProSpon spol. s.r.o. - Contipro a.s.
Method of use
A - Výsledek využívá pouze poskytovatel
Usage type
A - K využití výsledku jiným subjektem je vždy nutné nabytí licence