In situ hydroxyapatite synthesis enhances biocompatibility of pva/ha hydrogels

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985891%3A_____%2F21%3A00546168" target="_blank" >RIV/67985891:_____/21:00546168 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/22/17/9335" target="_blank" >https://www.mdpi.com/1422-0067/22/17/9335</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22179335" target="_blank" >10.3390/ijms22179335</a>

Result language
angličtina
Original language name
In situ hydroxyapatite synthesis enhances biocompatibility of pva/ha hydrogels
Original language description
Bone tissue engineering tries to simulate natural behavior of hard tissues. This study aimed to produce scaffolds based on polyvinyl alcohol (PVA) and hyaluronic acid (HA) with hy-droxyapatite (HAp) incorporated in two different ways, by in situ synthesis and physical mixing of pre-prepared HAp. In situ synthesis resulted in calcium deficient form of HAp with lower crystal-linity. The proliferation of human osteoblast-like cells MG-63 proved to be better in the scaffolds with in situ synthesized HAp compared to those with physically mixed pre-prepared HAp. For scaffolds with PVA/HA/HAp ratio 3:1:2, there was significantly higher initial adhesion (p = 0.0440), as well as the proliferation in the following days (p < 0.001). It seemed to be advantageous improve the properties of the scaffold by in situ synthesizing of HAp directly in the organic matrix.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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