Lack of response to unaligned chromosomes in mammalian female gametes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F12%3A00380411" target="_blank" >RIV/67985904:_____/12:00380411 - isvavai.cz</a>

Alternative codes found

RIV/00027162:_____/12:#0000937

Result on the web

<a href="http://dx.doi.org/10.4161/cc.21398" target="_blank" >http://dx.doi.org/10.4161/cc.21398</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4161/cc.21398" target="_blank" >10.4161/cc.21398</a>

Result language

angličtina

Original language name

Lack of response to unaligned chromosomes in mammalian female gametes

Original language description

Chromosome segregation errors are highly frequent in mammalian female meiosis, and their incidence gradually increases with maternal age. The fate of aneuploid eggs is obviously dependent on the stringency of mechanisms for detecting unattached or repairing incorrectly attached kinetochores. In case of their failure, the newly formed embryo will inherit the impaired set of chromosomes, which will have severe consequences for its further development. Whether spindle assembly checkpoint (SAC) in oocytes is capable of arresting cell cycle progression in response to unaligned kinetochores was discussed for a long time. It is known that abolishing SAC increases frequency of chromosome segregation errors and causes precocious entry into anaphase; SAC, therefore, seems to be essential for normal chromosome segregation in meiosis I. However, it was also reported that for anaphase-promoting complex (APC) activation, which is a prerequisite for entering anaphase; alignment of only a critical mas

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell Cycle

ISSN

1538-4101

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

16

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

3011-3018

UT code for WoS article

000308004000019

EID of the result in the Scopus database

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