Signaling proteins in spinal parenchyma and dorsal root ganglion in rat with spinal injury-induced spasticity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F13%3A00395281" target="_blank" >RIV/67985904:_____/13:00395281 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.jprot.2013.06.028" target="_blank" >http://dx.doi.org/10.1016/j.jprot.2013.06.028</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jprot.2013.06.028" target="_blank" >10.1016/j.jprot.2013.06.028</a>

Result language

angličtina

Original language name

Signaling proteins in spinal parenchyma and dorsal root ganglion in rat with spinal injury-induced spasticity

Original language description

Development of progressive muscle spasticity resulting from spinal traumatic injury can be mediated by loss of local segmental inhibition and/or by an increased sensory afferent drive with resulting exacerbated ?-motoneuron activity. To identify potential contributions of neuroactive substances in the development of such spasticity state, we employed a well-defined spinal injury-evoked spasticity rat model. Signaling molecules were analyzed in the spinal parenchyma below the level of spinal injury and in the corresponding dorsal root ganglion cells using Kinex antibody microarrays. The results uncovered the involvement of angiogenesis and neurodegeneration pathways together with direct cross-talk mediated by several hub proteins with SH-2 domains. At 2and 5. weeks after transection, up-regulation of several proteins including CaMKIV, RON? and PKC? as well as MAPK3/ERK1 phosphorylation was observed in the spinal ventral horns. Our results indicate that these signaling molecules and the

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Proteomics

ISSN

1874-3919

e-ISSN

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Volume of the periodical

91

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

17

Pages from-to

41-57

UT code for WoS article

000327906000004

EID of the result in the Scopus database

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