Molecular mechanisms of neuropathological changes in Alzheimer's disease: a review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F13%3A00425399" target="_blank" >RIV/67985904:_____/13:00425399 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/13:00065652 RIV/61988987:17110/13:A14019VF

Result on the web

<a href="http://dx.doi.org/10.5114/fn.2013.34190" target="_blank" >http://dx.doi.org/10.5114/fn.2013.34190</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/fn.2013.34190" target="_blank" >10.5114/fn.2013.34190</a>

Result language

angličtina

Original language name

Molecular mechanisms of neuropathological changes in Alzheimer's disease: a review

Original language description

More than 100 years after description of Alzheimer's disease (AD), two major pathological processes observed already by Alois Alzheimer, remain as the main explanation of the pathogenesis of Alzheimer's disease. Important molecular interactions leading to AD neuropathology were described in amyloid cascade and in tau protein function. No clinical trials with novel therapies based on amyloid cascade and tau protein hypotheses have been successful. The main aim of recent research is focused on the question what is primary mechanism leading to the molecular development of AD pathology Promising explanation of triggering mechanism can be seen in vascular pathology that have direct influence on the development of pathological processes typical for Alzheimerdisease. Novel insight into a number of cellular signaling mechanisms, as well as mitochondrial function in Alzheimer disease could also bring explanations of initial processes leading to the development of this pathology.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NT11152" target="_blank" >NT11152: Epidemiology and genetics of Alzheimer´s disease</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Neuropathologica

ISSN

1641-4640

e-ISSN

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Volume of the periodical

51

Issue of the periodical within the volume

1

Country of publishing house

PL - POLAND

Number of pages

9

Pages from-to

1-9

UT code for WoS article

000317316400001

EID of the result in the Scopus database

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