Challenges of Huntington's disease and quest for therapeutic biomarkers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F15%3A00441650" target="_blank" >RIV/67985904:_____/15:00441650 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/prca.201400073" target="_blank" >http://dx.doi.org/10.1002/prca.201400073</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/prca.201400073" target="_blank" >10.1002/prca.201400073</a>

Result language

angličtina

Original language name

Challenges of Huntington's disease and quest for therapeutic biomarkers

Original language description

Huntington's disease (HD) is the most common inherited neurodegenerative disorder among polyglutamine (polyQ) diseases caused by cytosine-adenine-guanine repeat expansion in exon 1 of the huntingtin gene whose translation results in polyQ stretch in theN-terminus of the huntingtin protein (HD protein). This mutation significantly affects huntingtin conformation, proteolysis, PTMs, as well as its ability to bind interacting proteins. As a consequence, a variety of cellular mechanisms such as transcription, mitochondrial energy metabolism, axonal transport, neuronal vulnerability to oxidative stress, neurotransmission, and immune response are altered and involved in the pathogenesis of HD. Promising candidate molecular biomarkers of HD have emerged fromproteomic studies. Recent analyses focused on HD protein itself, its PTM, and interacting proteins, which are of great importance for disease course. Furthermore, brain, body fluids, and immune system are intensively studied in order to

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Proteomics Clinical Applications

ISSN

1862-8346

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

1-2

Country of publishing house

DE - GERMANY

Number of pages

12

Pages from-to

147-158

UT code for WoS article

000349436400015

EID of the result in the Scopus database

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