Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F16%3A00467401" target="_blank" >RIV/67985904:_____/16:00467401 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/16:A1601GI3 RIV/00216224:14310/16:00088953

Result on the web

<a href="http://dx.doi.org/10.1016/j.jns.2016.01.022" target="_blank" >http://dx.doi.org/10.1016/j.jns.2016.01.022</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2016.01.022" target="_blank" >10.1016/j.jns.2016.01.022</a>

Result language

angličtina

Original language name

Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index

Original language description

Dementias of old age, in particular Alzheimer's disease (AD), pose a growing threat to the longevity and quality of life of individuals as well as whole societies world-wide. The risk factors are both genetic and environmental (lifestyle) and there is an overlap with similar factors predisposing to cardiovascular diseases (CVD). Using a case control genetic approach, we have identified a SNP (rs10507391) in ALOX5 gene, previously associated with an increased risk of stroke, as a novel genetic risk factor for AD. ALOX5 gene encodes a 5'-lipoxygenase (5'-LO) activating protein (FLAP), a crucial component of the arachidonic acid/leukotriene inflammatory cascade. A allele of rs4769874 polymorphism increases the risk of AD 1.41-fold (p < 0.0001), while AA genotype. does so 1.79-fold (p < 0.0001). In addition, GG genotype of rs4769874 polymorphism is associated with a modest increase in body mass index (BMI). We discuss potential biochemical mechanisms linking the SNP to AD and suggest possible preventive pharmacotherapies some of which are based on commonly available natural products. Finally, we set the newly identified AD risk factors into a broader context of similar CVD risk factors to generate a more comprehensive picture of interacting genetics and life-style habits potentially leading to the deteriorating mental health in the old age.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NT11152" target="_blank" >NT11152: Epidemiology and genetics of Alzheimer´s disease</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

—

Volume of the periodical

362

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

27-32

UT code for WoS article

000372558400005

EID of the result in the Scopus database

2-s2.0-84960859031