A comparison of two endoscopic closures: over-the-scope clip (OTSC) versus KING closure (endoloop plus clips) in a randomized long-term experimental study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F16%3A00469025" target="_blank" >RIV/67985904:_____/16:00469025 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/16:10331854 RIV/00023001:_____/16:00060101

Result on the web

<a href="http://dx.doi.org/10.1007/s00464-016-4831-z" target="_blank" >http://dx.doi.org/10.1007/s00464-016-4831-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00464-016-4831-z" target="_blank" >10.1007/s00464-016-4831-z</a>

Result language

angličtina

Original language name

A comparison of two endoscopic closures: over-the-scope clip (OTSC) versus KING closure (endoloop plus clips) in a randomized long-term experimental study

Original language description

Both over-the-scope clip (OTSC) and KING (endoloop + clips) closures provide reliable and safe full-thickness endoscopic closure. Nevertheless, OTSC clip demonstrated significantly inferior histological healing in the short-term follow-up. nTo compare OTSC versus KING closure of a perforation with regard to long-term effectiveness and macroscopic and histological quality of healing. nWe performed a randomized experimental study with 16 mini-pigs (mean weight 43.2 +/- 11.2 kg). A standardized perforation was performed on the anterior sigmoid wall. KING closure (n = 8) was attained by approximation of an endoloop fixed to the margins of a perforation with endoclips. OTSC closure (n = 8) was performed by deploying OTSC (OVESCO) over the defect. Pigs underwent a control sigmoidoscopy 8 months after the closure to assess the macroscopic quality of healing. Then, autopsy was performed and the rectosigmoid was sent for histopathological assessment. nAll closures were completed successfully without air leaks. The duration of closure was similar in both techniques (OTSC 17.8 +/- 7.6 min vs. KING 19.6 +/- 8.8 min). At autopsy, all KING closures (100 %) were healed with a flat scar without signs of leakage. Microscopically, no inflammatory changes were observed after KING closure. In the OTSC group, microscopic ulcers were present in two pigs (25 %), cryptal abscesses in three pigs (38 %) and significant neutrophil accumulation in all eight pigs (P < 0.01). Giant cell granulomas, dysplasia or abundant scarification was not observed in either group.nBoth OTSC and KING closures offer a long-term reliable seal of a gastrointestinal perforation without stenosis or fistulas. KING closure provides long-term histologically superior healing.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Surgical Endoscopy and Other Interventional Techniques

ISSN

0930-2794

e-ISSN

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Volume of the periodical

30

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

4910-4916

UT code for WoS article

000387225600028

EID of the result in the Scopus database

2-s2.0-84960102261