Prostaglandin E2 stimulates the expression of cumulus expansion-related genes in pigs: the role of protein kinase B
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F17%3A00475936" target="_blank" >RIV/67985904:_____/17:00475936 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/17:10338406
Result on the web
<a href="http://dx.doi.org/10.1016/j.prostaglandins.2017.04.001" target="_blank" >http://dx.doi.org/10.1016/j.prostaglandins.2017.04.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.prostaglandins.2017.04.001" target="_blank" >10.1016/j.prostaglandins.2017.04.001</a>
Alternative languages
Result language
angličtina
Original language name
Prostaglandin E2 stimulates the expression of cumulus expansion-related genes in pigs: the role of protein kinase B
Original language description
The production of prostaglandin E2 (PGE2) seems to play an important role in the ovulation process. PGE2 was found to induce cumulus expansion and meiosis resumption in mice, but little is known about its role in pigs. The goals of this study were (a) to assess the effect of PGE2 on the expression levels of cumulus expansion-related genes, (b) to define the signaling pathways that drive the PGE2-stimulated expression of cumulus expansion related genes, (c) to measure the effect of PGE2 on the activation of key signaling molecules (MAPK3/1, PKB) and on hyaluronan production in cumulus cells, and (d) to assess the effect of PGE2 on meiosis resumption. We documented that PGE2 is able to induce the expression of cumulus expansion-related genes (HAS2, TNFAIP6) as well as genes involved in steroidogenesis (CYP11A1) or prostaglandin production (PTGS2). PGE2 is able to activate PKB and MAPK3/1 and induce mild cumulus expansion and meiosis resumption, but less efficiently than FSH.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10604 - Reproductive biology (medical aspects to be 3)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Prostaglandins & Other Lipid Mediators
ISSN
1098-8823
e-ISSN
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Volume of the periodical
130
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
38-46
UT code for WoS article
000403527200006
EID of the result in the Scopus database
2-s2.0-85017374167