Statins do not inhibit the FGFR signaling in chondrocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F17%3A00480628" target="_blank" >RIV/67985904:_____/17:00480628 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/17:00067113 RIV/00216224:14110/17:00097411
Result on the web
<a href="http://dx.doi.org/10.1016/j.joca.2017.05.014" target="_blank" >http://dx.doi.org/10.1016/j.joca.2017.05.014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.joca.2017.05.014" target="_blank" >10.1016/j.joca.2017.05.014</a>
Alternative languages
Result language
angličtina
Original language name
Statins do not inhibit the FGFR signaling in chondrocytes
Original language description
Objective: Statins are widely used drugs for cholesterol lowering, which were recently found to counteract the effects of aberrant fibroblast growth factor receptor (FGFR3) signaling in cell and animal models of FGFR3-related chondrodysplasia. This opened an intriguing therapeutic possibility for human dwarfing conditions caused by gain-of-function mutations in FGFR3, although the mechanism of statin action on FGFR3 remains unclear. Here, we determine the effect of statins on FGFR signaling in chondrocytes. nDesign: Cultured chondrocyte cell lines, mouse embryonic tibia cultures and limb bud micromasses were treated with FGF2 to activate FGFR signaling. The effects of atorvastatin, fluvastatin, lovastatin and pravastatin on FGFR3 protein stability and on FGFR-mediated chondrocyte growth-arrest, loss of extracellular matrix (ECM), induction of premature senescence and hypertrophic differentiation were evaluated. nResults: Statins did not alter the level of FGFR3 protein expression nor produce any effect on FGFR-mediated inhibition of chondrocyte proliferation and hypertrophic differentiation in cultured chondrocyte cell lines, mouse tibia cultures or limb bud micromasses. nConclusion: We conclude that statins do not inhibit the FGFR signaling in chondrocytes. Therefore the statin-mediated rescue of FGFR3-related chondrodysplasia, described before, is likely not intrinsic to the growth plate cartilage.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Osteoarthritis and Cartilage
ISSN
1063-4584
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
1522-1530
UT code for WoS article
000407934000019
EID of the result in the Scopus database
2-s2.0-85020752812