Significance of epidermal growth factor receptor signaling for acquisition of meiotic and developmental competence in mammalian oocytes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F17%3A00483009" target="_blank" >RIV/67985904:_____/17:00483009 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1093/biolre/iox112" target="_blank" >http://dx.doi.org/10.1093/biolre/iox112</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/biolre/iox112" target="_blank" >10.1093/biolre/iox112</a>

Result language

angličtina

Original language name

Significance of epidermal growth factor receptor signaling for acquisition of meiotic and developmental competence in mammalian oocytes

Original language description

The surge in luteinizing hormone (LH) in preovulatory ovarian follicles triggers the resumption of oocyte meiosis accompanied by expansion of surrounding cumulus cells and ovulation of cumulus-oocyte complexes (COCs) into the oviduct. Over the last 15 years, substantial progress has been made in elucidating the key pathways by which the LH signal spreads within the preovulatory follicle and in identifying the molecules responsible for maintaining oocyte arrest and meiosis resumption. It is now clear that the adenylcyclase-mediated rise in intracellular cyclic adenosine monophosphate leads to activation of the epidermal growth factor receptor (EGFR) network in granulosa and cumulus cells. This signaling network can control the transcription of key genes required for cell metabolism, cumulus expansion, and oocyte meiosis resumption. In addition, EGFR signaling is involved in the regulation of gap junctional communication within follicular somatic cells, and in this way it can control the diffusion of meiosis-arresting molecules as well as energy substrates into the oocyte. Thus, the proper functioning of the follicular EGFR network is a vital precondition for the production of matured and developmentally competent oocytes. However, most current in vitro maturation systems are based on a culture of COCs isolated from growing follicles, in which function of the EGFR network may be insufficient for promoting oocyte meiotic and developmental competence. This review focuses on research identifying the importance of the EGFR signaling in somatic follicular cells for oocyte meiotic and developmental competence, and on special approaches to the culture of COCs isolated from growing follicles to promote oocyte quality.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10604 - Reproductive biology (medical aspects to be 3)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biology of Reproduction

ISSN

0006-3363

e-ISSN

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Volume of the periodical

97

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

537-549

UT code for WoS article

000416323500005

EID of the result in the Scopus database

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