Porcine Model of Huntington´s Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F17%3A00483018" target="_blank" >RIV/67985904:_____/17:00483018 - isvavai.cz</a>

Result on the web

<a href="https://www.intechopen.com/books/huntington-s-disease-molecular-pathogenesis-and-current-models/porcine-model-of-huntington-s-disease" target="_blank" >https://www.intechopen.com/books/huntington-s-disease-molecular-pathogenesis-and-current-models/porcine-model-of-huntington-s-disease</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/66353" target="_blank" >10.5772/66353</a>

Result language

angličtina

Original language name

Porcine Model of Huntington´s Disease

Original language description

At present, we are probably the only research facility to be breeding transgenic Huntington's disease minipigs (TgHD). These minipigs express N‐terminal part of human mutated huntingtin including 124Q under the control of human huntingtin promoter. The founder animal, born in 2009, gave birth to four subsequent generations with an equal contribution of wild‐type (WT) and transgenic (TgHD) piglets in all litters. We take different approaches, some of which are unique for large animal models, to study the phenotype development comparing WT and TgHD siblings. In this chapter, we review these approaches and the phenotype progression in the minipigs. Additionally, we outline perspectives in generation of new models using novel methodology and the potential of pig models in preclinical HD studies.

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

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OECD FORD branch

30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

Project

<a href="/en/project/LO1609" target="_blank" >LO1609: Models of the Serious Human Diseases: Traumatic Spinal Cord Injury, Huntington’s Disease, Melanoma and Infertility</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

Huntington´s Disease - Molecular Pathogenesis and Current Models

ISBN

978-953-51-3050-5

Number of pages of the result

20

Pages from-to

75-94

Number of pages of the book

150

Publisher name

Intech

Place of publication

London

UT code for WoS chapter

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