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Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F18%3A00490448" target="_blank" >RIV/67985904:_____/18:00490448 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/18:00102732

  • Result on the web

    <a href="http://dx.doi.org/10.1126/scitranslmed.aam6651" target="_blank" >http://dx.doi.org/10.1126/scitranslmed.aam6651</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1126/scitranslmed.aam6651" target="_blank" >10.1126/scitranslmed.aam6651</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs

  • Original language description

    The use of autologous (or syngeneic) cells derived from induced pluripotent stem cells (iPSCs) holds great promise for future clinical use in a wide range of diseases and injuries. It is expected that cell replacement therapies using autologous cells would forego the need for immunosuppression, otherwise required in allogeneic transplantations. However, recent studies have shown the unexpected immune rejection of undifferentiated autologous mouse iPSCs after transplantation. Whether similar immunogenic properties are maintained in iPSC-derived lineage-committed cells (such as neural precursors) is relatively unknown. We demonstrate that syngeneic porcine iPSC-derived neural precursor cell (NPC) transplantation to the spinal cord in the absence of immunosuppression is associated with long-term survival and neuronal and glial differentiation. No tumor formation was noted. Similar cell engraftment and differentiation were shown in spinally injured transiently immunosuppressed swine leukocyte antigen (SLA)-mismatched allogeneic pigs. These data demonstrate that iPSC-NPCs can be grafted into syngeneic recipients in the absence of immunosuppression and that temporary immunosuppression is sufficient to induce long-term immune tolerance after NPC engraftment into spinally injured allogeneic recipients. Collectively, our results show that iPSC-NPCs represent an alternative source of transplantable NPCs for the treatment of a variety of disorders affecting the spinal cord, including trauma, ischemia, or amyotrophic lateral sclerosis.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

    <a href="/en/project/LO1609" target="_blank" >LO1609: Models of the Serious Human Diseases: Traumatic Spinal Cord Injury, Huntington’s Disease, Melanoma and Infertility</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Science Translational Medicine

  • ISSN

    1946-6234

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    440

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    14

  • Pages from-to

  • UT code for WoS article

    000431766400001

  • EID of the result in the Scopus database

    2-s2.0-85047080924