BATTERY OF TESTS ASSESSED TO MONITOR MOTOR AND COGNITIVE FUNCTIONS OF TRANSGENIC HUNTINGTON'S DISEASE MINIPIG MODEL
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F18%3A00498968" target="_blank" >RIV/67985904:_____/18:00498968 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
BATTERY OF TESTS ASSESSED TO MONITOR MOTOR AND COGNITIVE FUNCTIONS OF TRANSGENIC HUNTINGTON'S DISEASE MINIPIG MODEL
Original language description
Hunting for the cure for Huntington´s disease (HD) requires extended pre-clinical studies to screen the safety, tolerability and efficacy of the potential therapeutic treatments. Therefore, the large animal models were developed for translational research to human studies. The battery of tests was designed for monitoring of phenotype similarity of the transgenic HD minipig model with HD patients.nMotor and cognitive functions were monitored in the group of transgenic (tgHD) and wild-type (wt) minipigs in different ages in the 3 following years.nThe results showed differences between tgHD and wt animals. The sex-related differences were observed in performance of the tests. The motor and cognitive functions deteriorated with ageing. TgHD animals have started to lose their weight from the age of 4 years.nThe data showed that the tests are safe and perspective for longitudinal studies. Moreover, tests can discern differences between tgHD and wt animals what enables to assess safety and efficacy of potential HD treatments in pre-clinical studies prior to human clinical trials.n
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/LO1609" target="_blank" >LO1609: Models of the Serious Human Diseases: Traumatic Spinal Cord Injury, Huntington’s Disease, Melanoma and Infertility</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů