Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F19%3A00504030" target="_blank" >RIV/67985904:_____/19:00504030 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/19:00107404 RIV/00159816:_____/19:00071073 RIV/60076658:12310/19:43899170
Result on the web
<a href="https://www.pnas.org/content/116/10/4316" target="_blank" >https://www.pnas.org/content/116/10/4316</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.1800338116" target="_blank" >10.1073/pnas.1800338116</a>
Alternative languages
Result language
angličtina
Original language name
Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase
Original language description
Vertebrate primary cilium is a Hedgehog signaling center but the extent of its involvement in other signaling systems is less well understood. This report delineates a mechanism by which fibroblast growth factor (FGF) controls primary cilia. Employing proteomic approaches to characterize proteins associated with the FGF-receptor, FGFR3, we identified the serine/threonine kinase intestinal cell kinase (ICK) as an FGFR interactor. ICK is involved in ciliogenesis and participates in control of ciliary length. FGF signaling partially abolished ICK's kinase activity, through FGFR-mediated ICK phosphorylation at conserved residue Tyr15, which interfered with optimal ATP binding. Activation of the FGF signaling pathway affected both primary cilia length and function in a manner consistent with cilia effects caused by inhibition of ICK activity. Moreover, knockdown and knockout of ICK rescued the FGF-mediated effect on cilia. We provide conclusive evidence that FGF signaling controls cilia via interaction with ICK.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
116
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
4316-4325
UT code for WoS article
000460242100061
EID of the result in the Scopus database
2-s2.0-85062661279