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Stenting to prevent esophageal stricture after circumferential endoscopic submucosal dissection: an experimental study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536364" target="_blank" >RIV/67985904:_____/20:00536364 - isvavai.cz</a>

  • Alternative codes found

    RIV/46747885:24410/20:00007929 RIV/00023001:_____/20:00080294 RIV/61988987:17110/20:A2202DDZ

  • Result on the web

    <a href="https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1261-3103" target="_blank" >https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1261-3103</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1055/a-1261-3103" target="_blank" >10.1055/a-1261-3103</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Stenting to prevent esophageal stricture after circumferential endoscopic submucosal dissection: an experimental study

  • Original language description

    Background and study aims Circular ESD (CESD) is a treatment option for patients with extensive early esophageal cancer. Its major drawback is the development of a stricture. Stenting may represent an attractive prevention strategy. We designed an experimental study to assess the effect of stents covered with acellular biomatrix ( AB) and a drug-eluting stent. nMaterials and methods Thirty- five 35 pigs underwent CESD and were randomized into six groups: G1 (control), G2 ( SEMS), G3 (SEMS+ AB), G4 (SEMS+ AB+ steroid-eluting layer), G5 (biodegradable stent [BD]), G6 (BD + AB). SEMS were placed alongside the post- CESD defect, fixed and removed after 21 days. The main outcomes were stricture development, severity, and histopathology. nResults Pigs with BD stents (G5, 6) experienced severe inflammation and hypergranulation without biodegradation, therefore, these groups were closed prematurely. Significant strictures developed in 29 of 30 pigs (96.7%). The most severe stricture developed in G2 and G4 (narrowest diameter (mm) 8.5 +/- 3, 3 (G2) and 8.6 +/- 2.1 ( G4) vs. 17 +/- 7.3 ( G1) and 13.5 +/- 8.3 ( G3), P < 0.01. Signs of re-epithelization were present in 67% and 71% in G1 and G2 and in 100% in G3 and G4. The most robust re- epithelization layer was present in G4. The inflammation was the most severe in G1 ( mean score 2.3) and least severe in G4 (0.4). nConclusions Stenting did not effectively prevent development of post-CESD esophageal stricture. SEMS with AB resulted in improved re-epithelization and decreased stricture severity. Steroid-eluting SEMS suppressed inflammation. BD stents seem inappropriate for this indication.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30212 - Surgery

Result continuities

  • Project

    <a href="/en/project/NV16-27653A" target="_blank" >NV16-27653A: Prevention of esophageal strictures after endoscopic resection or dissection of early esophageal neoplasia - experimental study</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Endoscopy International Open

  • ISSN

    2364-3722

  • e-ISSN

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    9

  • Pages from-to

    "E1698"-"E1706"

  • UT code for WoS article

    000581031400017

  • EID of the result in the Scopus database