The role of metalloproteinases in eye wounding and healing

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536566" target="_blank" >RIV/67985904:_____/20:00536566 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The role of metalloproteinases in eye wounding and healing
Original language description
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that play a significant role in extracellular matrix (ECM) remodelling, signal transduction, proliferation, migration, and contraction. MMPs are involved in tissue inflammation and leukocyte infiltration, and engaged in embryogenesis, morphogenesis, angiogenesis, and wound repair. Additionally, MMPs take part in the various processes during pathological conditions, including osteoarthritis, cancer, and neovascularization. All structures of the eye consist of a large amount of EXM that provides normal functioning of the ocular system. Therefore, even a little misbalance of MMPs and the tissue inhibitors of metalloproteases (TIMPs) in the eye tissue can lead to the disorders. Consequently, investigation of MMPs with TIMPs and elucidating molecular mechanisms is significant to further development of new therapies for eye disease treatment.
Czech name
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Czech description
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Project
<a href="/en/project/LO1609" target="_blank" >LO1609: Models of the Serious Human Diseases: Traumatic Spinal Cord Injury, Huntington’s Disease, Melanoma and Infertility</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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