Micronucleus as a mark of genome integrity problems
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536622" target="_blank" >RIV/67985904:_____/20:00536622 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Micronucleus as a mark of genome integrity problems
Original language description
Micronucleus (MN) is a small round and DNA containing structure located in the cytoplasm outside of the main nucleus. The presence of MN is considered as a sign of chromosomal instability. MN contains a part of an entire chromosome that was incorrectly segregated during anaphase and fail to incorporate into the daughter's cell nuclei correctly. Replication stress, un-replicated DNA, mitotic spindle defects, DNA damage, and non-functional DNA damage checkpoints are contributing to MN formation. Since zygote is a fundament of a whole new organism, the presence of MN in this cell can cause embryonal mortality, infertility or serious congenital disorders.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/LO1609" target="_blank" >LO1609: Models of the Serious Human Diseases: Traumatic Spinal Cord Injury, Huntington’s Disease, Melanoma and Infertility</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Translational Research in Serious Human Diseases
ISBN
978-80-200-3158-7
Number of pages of the result
8
Pages from-to
224-231
Number of pages of the book
271
Publisher name
Academia
Place of publication
Praha
UT code for WoS chapter
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