Oocyte specific lncRNA variant Rose influences oocyte and embryo development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F21%3A00543949" target="_blank" >RIV/67985904:_____/21:00543949 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2468054021000202?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2468054021000202?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ncrna.2021.06.001" target="_blank" >10.1016/j.ncrna.2021.06.001</a>
Alternative languages
Result language
angličtina
Original language name
Oocyte specific lncRNA variant Rose influences oocyte and embryo development
Original language description
Fully grown mammalian oocytes store a large amount of RNA synthesized during the transcriptionally active growth stage. A large part of the stored RNA belongs to the long non-coding class which contain either transcriptional noise or important contributors to cellular physiology. Despite the expanding number of studies related to lncRNAs, their influence on oocyte physiology remains enigmatic. We found an oocyte specific antisense, long non-coding RNA, Rose (lncRNA in Oocyte Specifically Expressed) expressed in two variants containing two and three non-coding exons, respectively. Rose is localized in the nucleus of transcriptionally active oocyte and in embryo with polysomal occupancy in the cytoplasm. Experimental overexpression of Rose in fully grown oocyte did not show any differences in meiotic maturation. However, knocking down Rose resulted in abnormalities in oocyte cytokinesis and impaired preimplantation embryo development. In conclusion, we have identified an oocyte-specific maternal lncRNA that is essential for successful mammalian oocyte and embryo development.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
<a href="/en/project/GA18-19395S" target="_blank" >GA18-19395S: Non-coding RNAs matters: role in mammalian oocyte and embryo</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Non-coding RNA research
ISSN
2468-2160
e-ISSN
2468-2160
Volume of the periodical
6
Issue of the periodical within the volume
2
Country of publishing house
CN - CHINA
Number of pages
7
Pages from-to
107-113
UT code for WoS article
000670265100007
EID of the result in the Scopus database
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