The retinal pigment epithelium: at the forefront of the blood-retinal barrier in physiology and disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F21%3A00554410" target="_blank" >RIV/67985904:_____/21:00554410 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/book/9780128185612/tissue-barriers-in-disease-injury-and-regeneration#book-description" target="_blank" >https://www.sciencedirect.com/book/9780128185612/tissue-barriers-in-disease-injury-and-regeneration#book-description</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-818561-2.00003-5" target="_blank" >10.1016/B978-0-12-818561-2.00003-5</a>
Alternative languages
Result language
angličtina
Original language name
The retinal pigment epithelium: at the forefront of the blood-retinal barrier in physiology and disease
Original language description
The blood-retinal barrier (BRB) has evolutionarily adapted as a protective border for the cell structures found in this very important sensory organ responsible for vision. The inner BRB with its endothelium, pericytes, Müller glia cells, and astrocytes are the first barrier between the blood and the retina, controlling nutrients and metabolites supply, as well as preventing toxic molecules to enter the retinal space. The outer BRB with its retinal pigment epithelium and the Bruch’s membrane serve as additional barrier and at the same time a front line for the most intense phagocytosis and intra- and transcellular transport in the human body, as well as the place of nearly highest oxidative stress versus antioxidative and angiogenic versus antiangiogenic processes. The barrier molecules in physiology and disease are discussed in this chapter (zonula occludens (ZO)-1, occludin, collagens). Finally, a brief overview of the tissue engineering and three-dimensional organoids with implications for future artificial generation of tissue and barriers in the eye is given. Understanding the structural and molecular components of the BRB and their implications in physiology and disease, as well as tissue engineering can shed light on the current state-of-the-art in basic and applied ophthalmology research and novel developments in therapy.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Tissue Barriers in Disease, Injury and Regeneration
ISBN
978-0-12-818561-2
Number of pages of the result
31
Pages from-to
115-146
Number of pages of the book
190
Publisher name
Elsevier
Place of publication
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UT code for WoS chapter
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