Cilia kinases in skeletal development and homeostasis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F22%3A00556562" target="_blank" >RIV/67985904:_____/22:00556562 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/22:00077559 RIV/00216224:14110/22:00125089
Result on the web
<a href="https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.426" target="_blank" >https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.426</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/dvdy.426" target="_blank" >10.1002/dvdy.426</a>
Alternative languages
Result language
angličtina
Original language name
Cilia kinases in skeletal development and homeostasis
Original language description
Primary cilia are dynamic compartments that regulate multiple aspects of cellular signaling. The production, maintenance, and function of cilia involve more than 1000 genes in mammals, and their mutations disrupt the ciliary signaling which manifests in a plethora of pathological conditions-the ciliopathies. Skeletal ciliopathies are genetic disorders affecting the development and homeostasis of the skeleton, and encompass a broad spectrum of pathologies ranging from isolated polydactyly to lethal syndromic dysplasias. The recent advances in forward genetics allowed for the identification of novel regulators of skeletogenesis, and revealed a growing list of ciliary proteins that are critical for signaling pathways implicated in bone physiology. Among these, a group of protein kinases involved in cilia assembly, maintenance, signaling, and disassembly has emerged. In this review, we summarize the functions of cilia kinases in skeletal development and disease, and discuss the available and upcoming treatment options.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Developmental Dynamics
ISSN
1058-8388
e-ISSN
1097-0177
Volume of the periodical
251
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
32
Pages from-to
577-608
UT code for WoS article
000708091000001
EID of the result in the Scopus database
2-s2.0-85117131883