Randomized experimental study of two novel techniques for transanal repair of dehiscent low rectal anastomosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F22%3A00557487" target="_blank" >RIV/67985904:_____/22:00557487 - isvavai.cz</a>
Alternative codes found
RIV/61383082:_____/21:00001050 RIV/00216208:11130/22:10430979 RIV/00023001:_____/22:00082652 RIV/00064165:_____/22:10430979
Result on the web
<a href="https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=57469107406" target="_blank" >https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=57469107406</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00464-021-08726-1" target="_blank" >10.1007/s00464-021-08726-1</a>
Alternative languages
Result language
angličtina
Original language name
Randomized experimental study of two novel techniques for transanal repair of dehiscent low rectal anastomosis
Original language description
Background Anastomotic leak after low anterior rectal resection is a dreadful complication. Early diagnosis, prompt management of sepsis followed by closure of anastomotic defect may increase chances of anastomotic salvage. In this randomized experimental study, we evaluated two different methods of trans-anal anastomotic repair. Methods A model of anastomotic leak was created in 42 male pigs. Laparoscopic low anterior resection was performed with anastomosis created using a circular stapler with half of the staples removed. Two days later, animals were randomized into a TAMIS (trans-anal minimally invasive surgery) repair, endoscopic suture (ENDO) or control group with no treatment (CONTROL). Signs of intraabdominal infection (IAI), macroscopic anastomotic healing and burst tests were evaluated to assess closure quality after animals were sacrificed on the ninth postoperative day. Results Closure was technically feasible in all 28 animals. Two animals had to be euthanized due to progressive sepsis at four and five days after endoscopic closure. Healed anastomosis with no visible defect was observed in 10/14 and 11/14 animals in TAMIS and ENDO groups, respectively, versus 2/14 in CONTROL (p < 0.05). Overall IAI rate was significantly lower in TAMIS (4/14, p = 0.006) and ENDO (5/14, p = 0.018) compared to CONTROL (12/14). Burst tests confirmed sealed closure in healed anastomosis with a median failure pressure of 190 (110-300) mmHg in TAMIS and 200 (100-300) mmHg in ENDO group (p = 0.644). Conclusion In this randomized experimental study, we found that both evaluated techniques are effective in early repair of dehiscent colorectal anastomosis with a high healing rate.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])
Result continuities
Project
<a href="/en/project/NV16-31806A" target="_blank" >NV16-31806A: New methods of in vivo monitoring and management of colonic anastomosis leak in experimental model</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Surgical Endoscopy and Other Interventional Techniques
ISSN
0930-2794
e-ISSN
1432-2218
Volume of the periodical
36
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
4050-4056
UT code for WoS article
000693853600001
EID of the result in the Scopus database
2-s2.0-85114394058