Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F22%3A00563611" target="_blank" >RIV/67985904:_____/22:00563611 - isvavai.cz</a>

Alternative codes found

RIV/00843989:_____/22:E0109565 RIV/00216224:14310/22:00127163 RIV/61988987:17110/22:A2302FPQ RIV/61989592:15110/22:73614995

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fgene.2022.848557/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fgene.2022.848557/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fgene.2022.848557" target="_blank" >10.3389/fgene.2022.848557</a>

Result language

angličtina

Original language name

Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Original language description

Carcinomas of the oral cavity and oropharynx belong among the ten most common malignancies in the human population. The prognosis of head and neck squamous cell carcinoma (HNSCC) is determined by the degree of invasiveness of the primary tumor and by the extent of metastatic spread into regional and distant lymph nodes. Moreover, the level of the perineural invasion itself associates with tumor localization, invasion's extent, and the presence of nodal metastases. Here, we summarize the current knowledge about different aspects of epigenetic changes, which can be associated with HNSCC while focusing on perineural invasion (PNI). We review epigenetic modifications of the genes involved in the PNI process in HNSCC from the omics perspective and specific epigenetic modifications in OSCC or other neurotropic cancers associated with perineural invasion. Moreover, we summarize DNA methylation status of tumor-suppressor genes, methylation and demethylation enzymes and histone post-translational modifications associated with PNI. The influence of other epigenetic factors on the HNSCC incidence and perineural invasion such as tobacco, alcohol and oral microbiome is overviewed and HPV infection is discussed as an epigenetic factor associated with OSCC and related perineural invasion. Understanding epigenetic regulations of axon growth that lead to tumorous spread or uncovering the molecular control of axon interaction with cancer tissue can help to discover new therapeutic targets for these tumors.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project

<a href="/en/project/NV19-08-00383" target="_blank" >NV19-08-00383: Prognostic and predictive markers of squamous cell carcinoma invasion in the oral cavity and oropharynx</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in genetics

ISSN

1664-8021

e-ISSN

1664-8021

Volume of the periodical

13

Issue of the periodical within the volume

APR 27

Country of publishing house

CH - SWITZERLAND

Number of pages

20

Pages from-to

848557

UT code for WoS article

000875197900001

EID of the result in the Scopus database

2-s2.0-85130643506