Diverse susceptibilities and responses of human and rodent cells to orthohantavirus infection reveal different levels of cellular restriction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F22%3A00569585" target="_blank" >RIV/67985904:_____/22:00569585 - isvavai.cz</a>
Result on the web
<a href="https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010844" target="_blank" >https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010844</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pntd.0010844" target="_blank" >10.1371/journal.pntd.0010844</a>
Alternative languages
Result language
angličtina
Original language name
Diverse susceptibilities and responses of human and rodent cells to orthohantavirus infection reveal different levels of cellular restriction
Original language description
Orthohantaviruses are zoonotic RNA viruses found all over the world in association with small mammal reservoirs. When occasionally transmitted to humans by aerosol they can cause two main types of diseases: hemorrhagic fever with renal syndrome (HFRS) mainly in Europe and Asia and hantavirus cardiopulmonary syndrome (HCPS) in North and South America with a case fatality rate of up to 15% and 40% respectively. An increasing number of outbreaks are recorded in endemic areas and, with disturbance of rodent habitats, climate change and the risk of virus genome reassortment, the emergence of new orthohantaviruses is of concern. With no treatment, no vaccines and few molecular tools, little is known about the pathophysiology of these viruses. Our comparative study of the viral cycle and interaction of different pathogenic and low or non-pathogenic orthohantaviruses in cells derived from human or rodent hosts reveals differences in entry, RNA replication or release of infectious particles, concurrently to regulation of host genes. This study illustrates how the development of a rodent host cell model together with the availability of an annotated bank vole genome may contribute to a better understanding of mechanisms of the interactions between orthohantaviruses and their hosts.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS Neglected Tropical Diseases
ISSN
1935-2735
e-ISSN
1935-2735
Volume of the periodical
16
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
41
Pages from-to
e0010844
UT code for WoS article
000922587500058
EID of the result in the Scopus database
2-s2.0-85140658520