Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00575031" target="_blank" >RIV/67985904:_____/23:00575031 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/23:00131746 RIV/00216305:26620/23:PU148889 RIV/46747885:24220/23:00011497 RIV/00216208:11110/23:10466882
Result on the web
<a href="https://www.science.org/doi/10.1126/sciadv.adi0482" target="_blank" >https://www.science.org/doi/10.1126/sciadv.adi0482</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/sciadv.adi0482" target="_blank" >10.1126/sciadv.adi0482</a>

Result language
angličtina
Original language name
Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development
Original language description
Mineralized tissues, such as bones or teeth, are essential structures of all vertebrates. They enable rapid movement, protection, and food processing, in addition to providing physiological functions. Although the development, regeneration, and pathogenesis of teeth and bones have been intensely studied, there is currently no tool to accurately follow the dynamics of growth and healing of these vital tissues in space and time. Here, we present the BEE-ST (Bones and tEEth Spatio-Temporal growth monitoring) approach, which allows precise quantification of development, regeneration, remodeling, and healing in any type of calcified tissue across different species. Using mouse teeth as model the turnover rate of continuously growing incisors was quantified, and role of hard/soft diet on molar root growth was shown. Furthermore, the dynamics of bones and teeth growth in lizards, frogs, birds, and zebrafish was uncovered. This approach represents an effective, highly reproducible, and versatile tool that opens up diverse possibilities in developmental biology, bone and tooth healing, tissue engineering, and disease modeling.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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