The mechanism of immune dysregulation caused by porcine reproductive and respiratory syndrome virus (PRRSV)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00578827" target="_blank" >RIV/67985904:_____/23:00578827 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/23:00578827 RIV/00027162:_____/23:N0000131
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1286457923000497?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1286457923000497?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.micinf.2023.105146" target="_blank" >10.1016/j.micinf.2023.105146</a>
Alternative languages
Result language
angličtina
Original language name
The mechanism of immune dysregulation caused by porcine reproductive and respiratory syndrome virus (PRRSV)
Original language description
PRRSV is capable of evading the effective immune response, thus persisting in piglets and throughout the swine herd. We show here that PRRSV invades the thymus and causes depletion of T-cell precursors and alteration of the TCR repertoire. Developing thymocytes are affected during negative selection when they transit from the triple-negative to triple-positive stages at the corticomedullary junction just before entering the medulla. The restriction of repertoire diversification occurs in both helper and cytotoxic abT cells. As a result, critical viral epitopes are tolerated, and infection becomes chronic. However, not all viral epitopes are tolerated. Infected piglets develop antibodies capable of recognizing PRRSV, but these are not virus neutralizing. Further analysis showed that the lack of an effective immune response against the critical viral structures results in the absence of a germinal center response, overactivation of T and B cells in the periphery, robust production of useless antibodies of all isotypes, and the inability to eliminate the virus. Overall, the results show how a respiratory virus that primarily infects and destroys myelomonocytic cells has evolved strategies to disrupt the immune system. These mechanisms may be a prototype for how other viruses can similarly modulate the host immune system.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA20-03282S" target="_blank" >GA20-03282S: Porcine reproductive and respiratory syndrome virus (PRRSV) alters thymocyte development and repertoire of T lymphocytes</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Microbes and Infection
ISSN
1286-4579
e-ISSN
1769-714X
Volume of the periodical
25
Issue of the periodical within the volume
7
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
13
Pages from-to
105146
UT code for WoS article
001083571800001
EID of the result in the Scopus database
2-s2.0-85170238533