Widened retinal arteriolar and venular diameters are not an endophenotype of schizophrenia: A one-time cross-sectional study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00581878" target="_blank" >RIV/67985904:_____/23:00581878 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/23:00133104 RIV/61988987:17110/23:A2402M7Q RIV/00216208:11150/23:10468843 RIV/00179906:_____/23:10468843 and 2 more

Result on the web

<a href="https://www.researchgate.net/publication/372807895_Widened_retinal_arteriolar_and_venular_diameters_are_not_an_endophenotype_of_schizophrenia_A_one-time_cross-sectional_study" target="_blank" >https://www.researchgate.net/publication/372807895_Widened_retinal_arteriolar_and_venular_diameters_are_not_an_endophenotype_of_schizophrenia_A_one-time_cross-sectional_study</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Widened retinal arteriolar and venular diameters are not an endophenotype of schizophrenia: A one-time cross-sectional study

Original language description

OBJECTIVES: Studies of schizophrenia endophenotypes may help clinicians better understand the etiopathogenesis and treatment of this mental disorder. The aim of the study was to determine if retinal arteriolar or venular abnormalities are an endophenotype of schizophrenia.nDESIGN: We performed a one-time cross-sectional study.nMATERIALS AND METHODS: We enlisted schizophrenic patients (n = 53) hospitalized in the Department of Psychiatry, University Hospital Hradec Kralove, their mentally healthy first-degree relatives (n = 53) and unrelated, age- and sex-matched mentally healthy controls (n = 49). We recorded all participants ' sociodemographic and, if relevant, clinical variables. Retinal imaging was carried out using a digital fundus camera (FF450 + IR). Outcomes included retinal vessel calibers measured using the software application VAMPIRE.nRESULTS: The study enrolled fifty-three schizophrenic patients (average age 32.1 years, males n = 38), an equal number of healthy relatives (average age 47.3 years, males n = 18), and forty-nine unrelated healthy controls (average age 32.2 years, males n = 35). Patients with schizophrenia had significantly increased retinal arteriolar diameters when compared to unrelated healthy controls (left eye p = 0.003, right eye p = 0.011) but not when compared to healthy relatives. The sizes of the retinal venules were not significantly different among the study groups.nCONCLUSIONS: Our cross-sectional findings do not support the notion that retinal microvascular anomalies are an endophenotype in schizophrenia. Longitudinal studies of this subject should be included in further research.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

2354-4716

Volume of the periodical

44

Issue of the periodical within the volume

5

Country of publishing house

SE - SWEDEN

Number of pages

296

Pages from-to

290-296

UT code for WoS article

001101642500003

EID of the result in the Scopus database

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