CPEB3 Maintains Developmental Competence of the Oocyte

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00586487" target="_blank" >RIV/67985904:_____/24:00586487 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2073-4409/13/10/850" target="_blank" >https://www.mdpi.com/2073-4409/13/10/850</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cells13100850" target="_blank" >10.3390/cells13100850</a>

Result language

angličtina

Original language name

CPEB3 Maintains Developmental Competence of the Oocyte

Original language description

Mammalian oocyte development depends on the temporally controlled translation of maternal transcripts, particularly in the coordination of meiotic and early embryonic development when transcription has ceased. The translation of mRNA is regulated by various RNA-binding proteins. We show that the absence of cytoplasmic polyadenylation element-binding protein 3 (CPEB3) negatively affects female reproductive fitness. CPEB3-depleted oocytes undergo meiosis normally but experience early embryonic arrest due to a disrupted transcriptome, leading to aberrant protein expression and the subsequent failure of embryonic transcription initiation. We found that CPEB3 stabilizes a subset of mRNAs with a significantly longer 3'UTR that is enriched in its distal region with cytoplasmic polyadenylation elements. Overall, our results suggest that CPEB3 is an important maternal factor that regulates the stability and translation of a subclass of mRNAs that are essential for the initiation of embryonic transcription and thus for embryonic development.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10605 - Developmental biology

Project

<a href="/en/project/GA22-27301S" target="_blank" >GA22-27301S: From meiosis to mitosis - is starting a new life under in vitro conditions equivalent to that in vivo?</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cells

ISSN

2073-4409

e-ISSN

2073-4409

Volume of the periodical

13

Issue of the periodical within the volume

10

Country of publishing house

CH - SWITZERLAND

Number of pages

18

Pages from-to

850

UT code for WoS article

001232965000001

EID of the result in the Scopus database

2-s2.0-85194129630